BDBM50638317 CHEMBL5557062

SMILES Cc1cc(CN2C(=O)[C@H](C)N(C)c3nc(Nc4cc(F)c(O)c(F)c4)ncc32)on1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50638317   

TargetCasein kinase I isoform epsilon(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human CK1 epsilon assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataKi:  8.30nMAssay Description:Inhibition of human CK1 delta assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase VRK1(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataKi:  38nMAssay Description:Inhibition of human VRK1 (3 to 364 residues) expressed in Escherichia coli BL21 (DE3)-R3 cells assessed as inhibition constant using human histone H3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataKi:  850nMAssay Description:Inhibition of human ROCK2 assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-6(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human RSK4 assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase alpha-3(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibition of human RSK2 assessed as inhibition constant by Cheng-Prusoff equation analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase VRK2(Human)
Universidade Estadual de Campinas

Curated by ChEMBL
LigandPNGBDBM50638317(CHEMBL5557062)
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of full-length VRK2 (unknown origin) using human histone H3 peptide as substrate preincubated for 30 mins followed by substrate and ATP ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed