BDBM50638715 CHEMBL5542997

SMILES O=C(NO)c1sccc1Nc1nc(Nc2ccc(N3CCOCC3)cc2)ncc1Cl

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50638715   

TargetEpidermal growth factor receptor(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50638715(CHEMBL5542997)
Affinity DataIC50: 12nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 50 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50638715(CHEMBL5542997)
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type EGFR (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 50 mins in presence of ATP b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50638715(CHEMBL5542997)
Affinity DataIC50: 16nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 50 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50638715(CHEMBL5542997)
Affinity DataIC50: 44nMAssay Description:Inhibition of EGFR L858R/T790M (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 50 mins in presence of ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Guizhou University

Curated by ChEMBL
LigandPNGBDBM50638715(CHEMBL5542997)
Affinity DataIC50: 214nMAssay Description:Inhibition of EGFR Del19/T790M (unknown origin) preincubated for 10 mins followed by substrate addition and measured after 50 mins in presence of ATP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed