BDBM50638922 CHEMBL5558410

SMILES COc1ccc(Cl)cc1-c1cc(C)ncc1C(=O)Nc1nnc(OCC2CCN(C(=O)c3cc(Cc4n[nH]c(=O)c5ccccc45)ccc3F)CC2)s1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50638922   

TargetPoly [ADP-ribose] polymerase 2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PARP2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 5.40nMAssay Description:Inhibition of human PARP1 incubated for 90 mins by colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 46nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) ATPase activity incubated for 60 mins in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP3(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 51nMAssay Description:Inhibition of PARP3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 88nMAssay Description:Inhibition of DNA polymerase theta mediated TMEJ repair activity in HEK293 cells incubated for 24 hrs by Nano-glo luciferase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 156nMAssay Description:Inhibition of PARP5b (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase TIPARP(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 194nMAssay Description:Inhibition of PARP7 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 206nMAssay Description:Inhibition of PARP5a (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP10(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of PARP10 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProtein mono-ADP-ribosyltransferase PARP8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50638922(CHEMBL5558410)
Affinity DataIC50: 2.93E+3nMAssay Description:Inhibition of PARP8 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed