BDBM50638978 CHEMBL5566114
SMILES O=c1ccc2c(N3C[C@@H]4[C@@H](CCP(=O)(O)O)[C@@H]4C3)ncnc2[nH]1
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50638978
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 3(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human ENPP3 using p-Nph-5'-TMP incubated for 40 mins by absorbance based analysisMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of human recombinant ENPP1 expressed in HEK293T cells using cGAMP as substrate at pH 7.5 measured after 3.5 hrs in presence of ATP by lumi...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 1(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of ENPP1 in human MDA-MB-231 cells using p-Nph-5'-TMP as substrate at pH 9.5 measured after 60 mins by spectrophotometry based analysisMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Shanghai Institute of Materia Medica
Curated by ChEMBL
Shanghai Institute of Materia Medica
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PDE4A using FAM-cAMP incubated for 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair