BDBM50639065 CHEMBL5567904

SMILES Nc1ccnc2cc(C(=O)Nc3ccccc3)[nH]c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50639065   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50639065(CHEMBL5567904)
Affinity DataKd:  9.40E+3nMAssay Description:Binding affinity to C-terminal 6His tagged full length SHP2 (1 to 528 residues) (unknown origin) transfected in Escherichia coli BL21(DE3) RIPL cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50639065(CHEMBL5567904)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant C-terminal truncated human SHP2 (1 to 530 residues) using 6,8-difluoro-4-methylumbelliferyl phosphate as substrate and H2N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50639065(CHEMBL5567904)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of SHP2 phosphatase-only domain (unknown origin) catalytic activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed