BDBM50639412 CHEMBL5562073

SMILES COc1cc(Nc2nccc(N3CCCn4nc(C#C[C@@](C)(O)c5nccs5)cc43)n2)cc(OC)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50639412   

TargetMitogen-activated protein kinase kinase kinase 14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639412(CHEMBL5562073)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of NIK (unknown origin) incubated 30 to 60 mins by ADP-Glo KinaseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639412(CHEMBL5562073)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of NIK (unknown origin) incubated 30 to 60 mins by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 14(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639412(CHEMBL5562073)
Affinity DataIC50: 1.19E+3nMAssay Description:Inhibition of NIK (unknown origin) expressed in COS-7 cells co-expressing NF-KappaB luciferase reporter assessed as suppression of luciferase reporte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPolycystin-2(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639412(CHEMBL5562073)
Affinity DataIC50: 4.03E+4nMAssay Description:Inhibition of PKD2 (unknown origin) by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639412(CHEMBL5562073)
Affinity DataIC50: 2.88E+5nMAssay Description:Inhibition of AMPKalpha1/beta1/gamma1 (unknown origin) by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 8(Human)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50639412(CHEMBL5562073)
Affinity DataIC50: 5.41E+5nMAssay Description:Inhibition of JNK1 (unknown origin) by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed