BDBM50639868 CHEMBL5562071

SMILES C=C(C)c1cccc([C@@H](N)CN(C)S(=O)(=O)c2cc(F)cc(F)c2)c1

InChI Key

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50639868   

TargetLysosomal acid glucosylceramidase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50639868(CHEMBL5562071)
Affinity DataKd:  50nMAssay Description:Binding affinity to human Avi/10-his tagged GCase (40 to 536 residues) expressed baculovirus expression system in Sf9 cells in assessed as dissociati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetLysosomal acid glucosylceramidase(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50639868(CHEMBL5562071)
Affinity DataEC50:  9.00E+3nMAssay Description:Positive allosteric modulation of GCase in human Fibroblast cells using GBA1-FQ2 as substrate preincubated for 24 hrs followed by substrate addition ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)