BDBM50640267 CHEMBL5555832

SMILES CN1CCN(C(=O)c2cc(Br)cc([N+](=O)[O-])c2N[C@@H]2CCCC[C@@H]2NC(=O)c2cc(=O)[nH]c3c(F)cccc23)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50640267   

TargetReplicase polyprotein 1ab(2019-nCoV)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataKd:  18nMAssay Description:Binding affinity to biotinylated SARS-CoV-2 3CLpro assessed as steady state dissociation constant incubated for 100 sec by biolayer interferometry an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant SARS-CoV-2 3CLpro expressed in Escherichia coli using MCA-AVLQSGFR-Lys(DNP)-Lys-NH2 as substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetReplicase polyprotein 1ab(HCoV-229E)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 2.56E+3nMAssay Description:Inhibition of HCov-229E 3CLpro by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
Target3C-like protease(Avian infectious bronchitis virus)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Infectious bronchitis virus 3CLpro by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCaspase-3(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Caspase-3 activity using Ac-DEVD-pNA as substrate incubated for 5 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCathepsin K(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin K using Z-Phe-Arg-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCathepsin D(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin D using MCA-PLGL-Dap(Dnp)-AR-NH2 as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCathepsin B(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin B using CBZ-Arg-Arg-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetCalpain-1 catalytic subunit(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Calpain 1 using N-Suc-Leu-Leu-Val-Tyr-7-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DPP-4 using Gly-Pro-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProthrombin(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human thrombin using benzoyl-FVR-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human trypsin using CBZ-Arg-Arg-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetProcathepsin L(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50640267(CHEMBL5555832)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Cathepsin L using Z-Phe-Arg-AMC as substrate incubated for 10 mins by FRET-enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed