BDBM50640274 CHEMBL4851009

SMILES O=C(O)Cc1nc(-c2ccccc2)c(-c2ccccc2)o1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50640274   

TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataKd:  300nMAssay Description:Binding affinity to human N-terminal His6 tagged Nurr1 LBD (362 to 598 residues) expressed in Escherichia coli BL21 (DE3)-R3-pRARE2 assessed as disso...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataIC50: 7.00E+3nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 LBD transfected in HEK293T cells assessed as suppression of Nurr1 activation incubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 1(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataIC50: 8.00E+3nMAssay Description:Inverse agonist activity at human Nur77 (358 to 598 residues) transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataIC50: 1.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 heterodimer transfected in HEK293T cells cotransfected with pFR-Luc-DR5 incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 3(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataIC50: 1.00E+4nMAssay Description:Inverse agonist activity at human NOR-1 (393 to 626 residues) transfected in HEK293T cells incubated for 16 hrs by firefly/renilla based Dual-Glo luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataIC50: 1.00E+4nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 monomer transfected in HEK293T cells cotransfected with pFR-Luc-NBRE incubated for 16 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetNuclear receptor subfamily 4 group A member 2(Human)
Ludwig-Maximilians-University of Munich

Curated by ChEMBL
LigandPNGBDBM50640274(CHEMBL4851009)
Affinity DataIC50: 1.20E+4nMAssay Description:Inverse agonist activity at Gal4-fused human full length Nurr1 homodimer transfected in HEK293T cells cotransfected with pFR-Luc-NurRE incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed