BDBM50640751 CHEMBL5573825

SMILES CCS(=O)(=O)Nc1cc(-c2cc(NC(C)=O)c(=O)n(C)c2)cc2c1ccn2C(C)(c1ccccn1)c1ccccn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50640751   

TargetBromodomain-containing protein 4(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50640751(CHEMBL5573825)
Affinity DataKd:  41nMAssay Description:Binding affinity to his-tagged human BRD4 BD2 assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50640751(CHEMBL5573825)
Affinity DataKd:  245nMAssay Description:Binding affinity to his6-tagged human BRD4 BD1 (44 to 168 residues) expressed in Escherichia coli Rossetta BL21 (DE3) cells assessed as dissociation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50640751(CHEMBL5573825)
Affinity DataIC50: 438nMAssay Description:Inhibition of N-terminal his6-tagged human BRD4 BD1 (44 to 168 residues) expressed in Escherichia coli Rossetta BL21 (DE3) cells incubated for 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetBromodomain-containing protein 4(Human)
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50640751(CHEMBL5573825)
Affinity DataIC50: 714nMAssay Description:Inhibition of N-terminal his6-tagged human BRD4 BD2 incubated for 15 mins by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed