BDBM50641290 CHEMBL5593687

SMILES CCc1cc2c(cc1-c1ccn(CCCN(C)C)n1)C(C)(C)c1[nH]c3cc(C#N)ccc3c1C2=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50641290   

TargetALK tyrosine kinase receptor(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type ALK (unknown origin) by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type His-tagged human RET by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 9nMAssay Description:Inhibition of RET V804L mutant (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Nanjing University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM50641290(CHEMBL5593687)
Affinity DataIC50: 23nMAssay Description:Inhibition of RET V804M mutant (unknown origin) by DiscoverX KINOMEscan assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed