BDBM50642013 US12344595, Example 1

SMILES NS(=O)(=O)c1cccc(NC(=O)c2cc(C(F)(F)F)cnc2N2CCC(F)(F)CC2)c1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50642013   

TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataEC50:  42nMAssay Description:Inhibition of recombinant human Nav1.8 expressed in HEK293 cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataIC50: 47nMAssay Description:TBDMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/22/2025
Entry Details
US Patent

TargetNuclear receptor subfamily 1 group I member 2(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataEC50:  2.30E+4nMAssay Description:Activation of PXR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 8 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of Nav1.6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 2 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of Nav1.2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandPNGBDBM50642013(US12344595, Example 1)
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed