BDBM50643520 CHEMBL5570019

SMILES Nc1nc2cc(CC[C@H]3C[C@@H](Nc4ncnc5c4C(=O)CCN5)[C@H](O)[C@@H]3O)ccc2cc1Br

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50643520   

TargetProtein arginine N-methyltransferase 5(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 13nMAssay Description:Inhibition of PRMT5 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 2.82E+3nMAssay Description:Inhibition of PRMT1 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 5.90E+3nMAssay Description:Inhibition of PRMT4 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of PRMT8 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD3 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of NSD2 methyltransferase activity (unknown origin) using histone H4/SAM as substrate incubated for 80 mins by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50643520(CHEMBL5570019)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of EZH2 (unknown origin) using SAM and peptide substrate by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed