BDBM50644230 CHEMBL5570975

SMILES Cn1ccc(-c2cc(Cl)c(Cl)c3[nH]c4c(c23)CC2(CC4)CCN(C(=O)CO)C2)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50644230   

TargetCyclic GMP-AMP synthase(Human)TBA
LigandPNGBDBM50644230(CHEMBL5570975)
Affinity DataIC50: 7.65E+3nMAssay Description:Inhibition of cGAS in dsDNA activated human THP1-Dual cells preincubated for 1 hr followed by cGAMP addition and measured after 24 hrs by luminescenc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Human)TBA
LigandPNGBDBM50644230(CHEMBL5570975)
Affinity DataIC50: 7.65E+3nMAssay Description:Inhibition of cGAS in human THP1-Dual cells preincubated for 1 hr followed by cGAMP addition and measured after 24 hrs by luminescence based QUANTI-L...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Mouse)TBA
LigandPNGBDBM50644230(CHEMBL5570975)
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of cGAS in dsDNA activated mouse RAW-Lucia ISG cells preincubated for 1 hr followed by cGAMP addition and measured after 24 hrs by lumines...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCyclic GMP-AMP synthase(Mouse)TBA
LigandPNGBDBM50644230(CHEMBL5570975)
Affinity DataIC50: 8.91E+3nMAssay Description:Inhibition of cGAS in mouse RAW-Lucia ISG cells preincubated for 1 hr followed by cGAMP addition and measured after 24 hrs by luminescence based QUAN...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
TBA
Entry Details
PubMed