BDBM50644703 CHEMBL5574945

SMILES Cc1cc(C(F)(F)F)c(C#N)c(N2C[C@@H](CO)[C@H]2C(=O)N(C)c2ccc(F)c(Cl)c2)n1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50644703   

TargetDNA polymerase theta(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50644703(CHEMBL5574945)
Affinity DataIC50: 22nMAssay Description:Inhibition of DNA polymerase theta (unknown origin) using 5-TAMRA-CCTTCCTCCCGTGTCTTGTACCTTCCCGTCAGGAGGAAGG-BHQ-3' as substrate incubated for 60 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA polymerase theta(Human)
Insilico Medicine Shanghai Ltd

Curated by ChEMBL
LigandPNGBDBM50644703(CHEMBL5574945)
Affinity DataIC50: 480nMAssay Description:Inhibition of DNA polymerase theta mediated TMEJ repair activity in human HEK293T cells transfected with TMEJ reporter incubated for 24 hrs by Nano-g...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed