BDBM50645879 CHEMBL5591970

SMILES O=C(Nc1cc(F)c(N(c2cccn3nccc23)C2CCC2)cc1F)c1ccnn(-c2ccc(F)cc2)c1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50645879   

TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645879(CHEMBL5591970)
Affinity DataIC50: 24nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET D1228N mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645879(CHEMBL5591970)
Affinity DataIC50: 30nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET Y1230H mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645879(CHEMBL5591970)
Affinity DataIC50: 158nMAssay Description:Inhibition of MET D1228N mutant (unknown origin) transfected in mouse NIH3T3 cells incubated for 1 hr by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50645879(CHEMBL5591970)
Affinity DataIC50: 222nMAssay Description:Displacement of tracer 236 from N-terminal GST-tagged recombinant human MET F1200I mutant (956 to end residues) expressed in Sf9 insect cells incubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed