BDBM50646361 CHEMBL5591922

SMILES O=C(O)C(Cn1c2ccc(Br)cc2c2cc(Br)ccc21)N1C(=O)c2ccccc2C1=O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50646361   

TargetDNA (cytosine-5)-methyltransferase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  40nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  1.16E+3nMAssay Description:Binding affinity to human DNMT1 expressed in Escherichia coli assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataKd:  4.09E+3nMAssay Description:Binding affinity to human DNMT1 in presence of 10 uM SAM by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50646361(CHEMBL5591922)
Affinity DataIC50: 3.82E+4nMAssay Description:Inhibition of DNMT1 (unknown origin) using semi-methylated DNA substrate preincubated for 15 mins followed by substrate and [3H-SAM] addition and mea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed