BDBM50646817 CHEMBL5591779

SMILES CC(=O)N[C@H]1CC[C@H](c2ncc(Cl)c(Nc3ccccc3S(=O)(=O)C(C)C)n2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50646817   

TargetCyclin-dependent kinase 7(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of CDK7 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 3(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 370nMAssay Description:Inhibition of CDK3 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 4(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 645nMAssay Description:Inhibition of CDK4 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 704nMAssay Description:Inhibition of CDK9 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 735nMAssay Description:Inhibition of CDK2 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 6(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.35E+3nMAssay Description:Inhibition of CDK6 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEphrin type-A receptor 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 2.48E+3nMAssay Description:Inhibition of human EPHA1 incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 2.89E+3nMAssay Description:Inhibition of human IGF1R incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 3.23E+3nMAssay Description:Inhibition of human TRKA incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 5(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 3.68E+3nMAssay Description:Inhibition of CDK5 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human LYN incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 1(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK1 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human HCK incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human EGFR incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Blk(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BLK incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human MET incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human recombinant BTK incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Tec(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human TEC incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Human)
Shanghai Institute of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50646817(CHEMBL5591779)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human BMX incubated for 1 hr by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed