BDBM50647974 CHEMBL5597218
SMILES COc1ncc(-c2ccn3nc(NC(=O)NCCOc4cccnc4)cc3c2)cc1OC(F)F
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50647974
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PI3:PS as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PI3:PS as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Inhibition of PI3Kdelta in human Raji cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: 28nMAssay Description:Inhibition of PI3Kgamma in mouse RAW264.7 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 2 hrs by Western blot anal...More data for this Ligand-Target Pair
Affinity DataEC50: 319nMAssay Description:Inhibition of PI3Kbeta in human 786-0 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 2 hrs by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Inhibition of PI3Kalpha in human SK-OV-3 cells assessed as reduction in AKT phosphorylation at S473 residue incubated for 2 hrs by Western blot analy...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K alpha (unknown origin) using PI3:PS as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair