BDBM50648038 CHEMBL5598116

SMILES CCCNNC(=O)c1ccc(Cn2cc(Nc3ncc(Cl)c(-c4cnc5ccccn45)n3)cn2)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50648038   

TargetHistone deacetylase 3(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC3 using Ac-Lys-Tyr-Lys(eta-acetyl)-AMC as substrate incubated for 24 hrs by fluorescence based Envision plate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 1(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant HDAC1 using Ac-Lys-Tyr-Lys(eta-acetyl)-AMC as substrate incubated for 24 hrs by fluorescence based Envision plate rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetRibosomal protein S6 kinase beta-1(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 371nMAssay Description:Inhibition of P70S6K (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 7(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 973nMAssay Description:Inhibition of CDK7 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 9(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.42E+3nMAssay Description:Inhibition of CDK9 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 2.38E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 9.13E+3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of AurorA (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin) using ULight 4EBP1 peptide as substrate incubated for 2 hrs in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetCyclin-dependent kinase 2(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17B(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DRAK2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant HDAC6 using Boc-Lys(eta-acetyl)-AMC as substrate incubated for 24 hrs by fluorescence based Envision plate reader ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
University of Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50648038(CHEMBL5598116)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of human recombinant HDAC4 using Ac-Leu-Gly-Lys(Tfa)-AMC as substrate incubated for 24 hrs by fluorescence based Envision plate reader ana...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed