BDBM50648056 CHEMBL5598288

SMILES Cc1c(C(=O)NS(=O)(=O)N(C)C)cc(-c2ccc(Cl)cc2)c2cc[nH]c12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50648056   

TargetAurora kinase A(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataKd:  79nMAssay Description:Binding affinity to 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as dissociation constan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataKd:  100nMAssay Description:Inhibition of 6-His-tagged human Aurora A (126 to 390 residues) expressed in Escherichia coli BL21 (DE3) cells/N-terminal his-tagged/GB-1 fused human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataEC50:  2.20E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as mislocalization of aurora A by measuring displacement from sp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetTargeting protein for Xklp2(Human)
University of Cambridge

Curated by ChEMBL
LigandPNGBDBM50648056(CHEMBL5598288)
Affinity DataEC50:  6.90E+3nMAssay Description:Inhibition of Aurora A-TPX2 protein-protein interaction in human HeLa cells assessed as reduction in aurora A phosphorylation at Thr288 residue incub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed