BDBM50648798 CHEMBL5612510

SMILES CCc1c(C#N)c(S[C@@H](C(N)=O)c2ccccc2)nc(N2CCC(CNCc3ccc(/C=C/C(=O)NO)cc3)CC2)c1C#N

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50648798   

TargetHistone deacetylase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 50nMAssay Description:Inhibition of HDAC1 (unknown origin) using Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 60nMAssay Description:Inhibition of HDAC extracted from human HeLa cell nucleus using Boc-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 3(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 90nMAssay Description:Inhibition of HDAC3 (unknown origin) using Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 8(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 240nMAssay Description:Inhibition of HDAC8 (unknown origin) using Boc-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 2(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 270nMAssay Description:Inhibition of HDAC2 (unknown origin) using Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetDNA (cytosine-5)-methyltransferase 1(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataEC50:  750nMAssay Description:Inhibition of NLuc-fused DNMT1 expressed hypomorphic in human HCT-116 cells assessed as TSG repoter activation at 3 uM incubated for 72 hrs by Nano-G...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 4(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 3.73E+3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Leu-Gly-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 5(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of HDAC5 (unknown origin) using Leu-Gly-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 6(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 1.17E+4nMAssay Description:Inhibition of HDAC6 (unknown origin) using Leu-Gly-Lys(Ac)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 7(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 1.42E+4nMAssay Description:Inhibition of HDAC7 (unknown origin) using Leu-Gly-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone deacetylase 9(Human)
Shandong University

Curated by ChEMBL
LigandPNGBDBM50648798(CHEMBL5612510)
Affinity DataIC50: 4.07E+4nMAssay Description:Inhibition of HDAC9 (unknown origin) using Leu-Gly-Lys(TFA)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed