BDBM50648859 CHEMBL5612066

SMILES C=CC(=O)N(Cc1ccc(Cl)cc1)c1ccc(O[C@@H]2CC[C@@H](N)C2)cc1

InChI Key

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50648859   

TargetBcl-2-related protein A1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648859(CHEMBL5612066)
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Bfl-1 (1 to 151 residues)(unknown origin) extracted from Escherichia coli BL21-Gold (DE3) using HyLi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBcl-2-related protein A1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648859(CHEMBL5612066)
Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal His6-tagged recombinant Bfl-1 (1 to 151 residues)(unknown origin) extracted from Escherichia coli BL21-Gold (DE3) using HyLi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetBcl-2-related protein A1(Human)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50648859(CHEMBL5612066)
Affinity DataEC50:  7.40E+3nMAssay Description:Inhibition of Bfl-1 in human SU-DHL-1 cells assessed as caspase-3/7 activation measured after 6 hrs by UPLC-MRM MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMedPDB3D3D Structure (crystal)