BDBM50648946 CHEMBL5613649

SMILES Nc1ncnc2c1ncn2[C@@H]1O[C@H](CSCCNCc2cccc(Br)c2)[C@@H](O)[C@H]1O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50648946   

TargetHistone-arginine methyltransferase CARM1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1nMAssay Description:Inhibition of human PRMT4 using histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-arginine methyltransferase CARM1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataKd:  188nMAssay Description:Binding affinity to PRMT4 (140 to 480 residues) (unknown origin) assessed as dissociation constant by ITC methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase NSD2(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human NSD2 using nucleosomes as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 7(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human PRMT7 using GST-GAR as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PRMT5/MEP50 using Histone H2 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 6(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of PRMT6 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 3(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PRMT3 using Histone H3 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 1(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PRMT1 using Histone H4 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetProtein arginine N-methyltransferase 8(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50648946(CHEMBL5613649)
Affinity DataIC50: 1.00E+7nMAssay Description:Inhibition of human PRMT8 using Histone H4 as substrate and SAM as cofactor by radiometric HotSpot assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed