BDBM50649664 CHEMBL5618748

SMILES COc1ccc2cc(-c3ccc(NS(=O)(=O)C(F)(F)F)cc3)ncc2c1O

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50649664   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataKd:  0.0210nMAssay Description:Binding affinity to recombinant human IDO1 assessed as dissociation rate constant at 0.78 to 25 uM by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataKd:  0.0350nMAssay Description:Binding affinity to recombinant human TDO assessed as dissociation rate constant at 0.78 to 25 uM by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataIC50: 80nMAssay Description:Inhibition of N-terminal His-tagged recombinant human TDO extracted from Escherichia coli Transetta (DE3) using L-tryptophan as substrate preincubate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataIC50: 310nMAssay Description:Inhibition of N-terminal His-tagged recombinant human IDO1 extracted from Escherichia coli Transetta (DE3) using L-tryptophan as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataKd:  450nMAssay Description:Binding affinity to recombinant human IDO1 assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataKd:  740nMAssay Description:Binding affinity to recombinant human TDO assessed as equilibrium dissociation constant by SPR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataIC50: 7.23E+3nMAssay Description:Inhibition of human TDO transfected in HEK293T cells using L-tryptophan as substrate incubated for 24 hrs by absorbance based microplate analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM50649664(CHEMBL5618748)
Affinity DataIC50: 9.29E+3nMAssay Description:Inhibition of IDO1 in IFN-gamma induced human HeLa cells using L-tryptophan as substrate incubated for 24 hrs by absorbance based microplate analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed