BDBM50649863 CHEMBL5624606

SMILES CC(C)n1c2cc(Nc3ccnc(-c4cnn(S(=O)(=O)C5CC5)c4)n3)ncc2c2c(OCC(F)(F)F)cc(N3CCN(C)CC3)cc21

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50649863   

TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50649863(CHEMBL5624606)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of wild type EGFR L858R/T790M/C797S triple mutant (unknown origin) phosphorylation expressed in mouse BaF3 cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50649863(CHEMBL5624606)
Affinity DataIC50: 0.25nMAssay Description:Inhibition of recombinant EGFR L858R/T790M/C797S mutant (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50649863(CHEMBL5624606)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant EGFR Del19/T790M/C797S mutant (unknown origin) in presence of ATP by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Hangzhou Normal University

Curated by ChEMBL
LigandPNGBDBM50649863(CHEMBL5624606)
Affinity DataIC50: 0.280nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) expressed in Bac-to-Bac baculovirus expression system measured after 2 hrs by ELI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed