BDBM50650461 CHEMBL5631094

SMILES C=CC(=O)Nc1cc(Nc2nccc(-c3cnc4c(C)cccn34)n2)c(OC)cc1N(C)CCN(C)C

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50650461   

TargetEpidermal growth factor receptor(Human)
Puhe Biopharma

Curated by ChEMBL
LigandPNGBDBM50650461(CHEMBL5631094)
Affinity DataIC50: 0.370nMAssay Description:Inhibition of GST-tagged recombinant human EGFR T790M/L858R mutant (668 to 1210 residues) expressed in Insect cells incubated for 60 mins in presence...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Puhe Biopharma

Curated by ChEMBL
LigandPNGBDBM50650461(CHEMBL5631094)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Puhe Biopharma

Curated by ChEMBL
LigandPNGBDBM50650461(CHEMBL5631094)
Affinity DataIC50: 11nMAssay Description:Inhibition of wildtype EGFR (unknown origin) incubated for 60 mins in presence of ATP by biochemical enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed