BDBM50650703 CHEMBL5630025

SMILES COc1cc(-c2cncc3c2COCc2cc(N4CCN(C)CC4)ccc2-3)cc(OC)c1OC

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50650703   

TargetActivin receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650703(CHEMBL5630025)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST-his6 tagged human recombinant ALK2 (145 to 509 residues) expressed in Sf9 insect cells in presence of ATP by ADP-glo ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650703(CHEMBL5630025)
Affinity DataIC50: 7nMAssay Description:Inhibition of ALK2 in human HEK293 cells using NanoGlo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650703(CHEMBL5630025)
Affinity DataIC50: 187nMAssay Description:Inhibition of N-terminal GST-his6 tagged human recombinant ALK5 (200 to 503 residues) expressed in Sf9 insect cells in presence of ATP by ADP-glo ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650703(CHEMBL5630025)
Affinity DataIC50: 347nMAssay Description:Inhibition of ALK5 (unknown origin) transfected in human HEK293 cells cotransfected with CAGA reporter encoding luciferase by Dual luciferase reporte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed