BDBM50650704 CHEMBL5630109

SMILES COc1cc(-c2cncc3c2CCOc2cc(N4CCNCC4)ccc2-3)cc(OC)c1OC

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50650704   

TargetActivin receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650704(CHEMBL5630109)
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal GST-his6 tagged human recombinant ALK2 (145 to 509 residues) expressed in Sf9 insect cells in presence of ATP by ADP-glo ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetActivin receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650704(CHEMBL5630109)
Affinity DataIC50: 6nMAssay Description:Inhibition of ALK2 in human HEK293 cells using NanoGlo as substrate incubated for 2 hrs by NanoBRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650704(CHEMBL5630109)
Affinity DataIC50: 224nMAssay Description:Inhibition of N-terminal GST-his6 tagged human recombinant ALK5 (200 to 503 residues) expressed in Sf9 insect cells in presence of ATP by ADP-glo ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTGF-beta receptor type-1(Human)
Ontario Institute for Cancer Research

Curated by ChEMBL
LigandPNGBDBM50650704(CHEMBL5630109)
Affinity DataIC50: 471nMAssay Description:Inhibition of ALK5 (unknown origin) transfected in human HEK293 cells cotransfected with CAGA reporter encoding luciferase by Dual luciferase reporte...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed