BDBM50650719 CHEMBL5633996
SMILES COc1c(C)cc(NC(=O)c2nn(Cc3ccc(F)cc3)c3c2CN(C(=O)c2ccc[nH]2)C[C@@H]3C(N)=O)cc1C
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50650719
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 8.80nMAssay Description:Inhibition of human N-terminal 6His-tagged IDH1 R132C mutant expressed in Escherichia coli Rosetta2 (DE3) in presence of alpha-ketoglutarate and NADP...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant IDH1 R132H mutant expressed in Escherichia coli BL21 (DE3) cells in presence of alpha-ketoglutarate and NADPH by fluo...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of wildtype human recombinant IDH1 R132H mutant heterodimer in presence of alpha-ketoglutarate and NADPH by fluorescence based biochemical...More data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Human)
Nanjing University of Chinese Medicine
Curated by ChEMBL
Nanjing University of Chinese Medicine
Curated by ChEMBL
Affinity DataIC50: 467nMAssay Description:Inhibition of N-terminal His-tagged wild type IDH1 (unknown origin)More data for this Ligand-Target Pair