BDBM50650836 CHEMBL5633185

SMILES Cn1cc(-c2cccc(NC(=O)c3cc4c(nc3O[C@H]3C[C@@H](O)C3)OC(C)(C)C4)n2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50650836   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataKd:  0.350nMAssay Description:Binding affinity to IRAK4 (unknown origin) by kinomescan competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 7.30nMAssay Description:Inhibition of IRAK4 (unknown origin) using FAM-labeled peptide as substrate incubated for 10 mins in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 9nMAssay Description:Inhibition of CLK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 11nMAssay Description:Inhibition of FLT3 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInterleukin-1 receptor-associated kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataKd:  13nMAssay Description:Binding affinity to IRAK1 (unknown origin) by kinomescan competition binding assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 34nMAssay Description:Inhibition of DYRK1A (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 17A(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 788nMAssay Description:Inhibition of DRAK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 4.69E+3nMAssay Description:Inhibition of RIPK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 8.35E+3nMAssay Description:Inhibition of RIPK2 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase 38(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 1.65E+4nMAssay Description:Inhibition of NDR1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of B-Raf (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 2.65E+4nMAssay Description:Inhibition of HIPK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase BTK(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of BTK (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetcAMP-dependent protein kinase catalytic subunit beta(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PKA-C beta (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of ASK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase PAK 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of PAK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CDK4/cyclinD3 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CaMKI (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMAP kinase-activated protein kinase 2(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MAPKAP-K2 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase MRCK alpha(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of MRCKa (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Soochow University

Curated by ChEMBL
LigandPNGBDBM50650836(CHEMBL5633185)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of JAK1 (unknown origin) by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed