BDBM50651620 CHEMBL5632436

SMILES Cn1nccc1-c1cc2c(Nc3ccc(OCc4ccccc4)cc3)ncnc2[nH]1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50651620   

TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataIC50: 69nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation (unknown origin) preincubated for 60 mins in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataIC50: 70nMAssay Description:Inhibition of EGFR L858R mutant phosphorylation (unknown origin) in the presence of ATPMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataKd:  210nMAssay Description:Binding affinity to human partial length EGFR (R669 to V1011 residues) L858R mutant expressed in bacterial expression system assessed as dissociation...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of AURKB/INCENP (unknown origin) preincubated for 60 mins in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataIC50: 3.02E+3nMAssay Description:Inhibition of EGFR L858R mutant (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of AURKB/INCENP (unknown origin) in the presence of ATP at Km concentrationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase B(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataKd: >3.00E+4nMAssay Description:Binding affinity to human partial length AURKB (D25 to A303 residues) expressed in mammalian system assessed as dissociation constant by DiscoverX ki...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Ferris State University

Curated by ChEMBL
LigandPNGBDBM50651620(CHEMBL5632436)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of EGFR (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell survivalMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed