BDBM50652203 CHEMBL5641915

SMILES CCN1CCN(c2ccc(Nc3nc(Nc4ccccc4N(C)S(C)(=O)=O)c4cc[nH]c4n3)cc2F)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50652203   

TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652203(CHEMBL5641915)
Affinity DataIC50: 9.20nMAssay Description:Inhibition of EGFR del19/T790M/C797S triple mutant (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652203(CHEMBL5641915)
Affinity DataIC50: 9.60nMAssay Description:Inhibition of EGFR phosphorylation in human PC-9 cells harboring Del19/T790M/C797S mutant incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652203(CHEMBL5641915)
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652203(CHEMBL5641915)
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A-431 cells harboring wild type EGFR incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652203(CHEMBL5641915)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed