BDBM50652205 CHEMBL5646609

SMILES CCN1CCN(C2CCN(c3ccc(Nc4nc(Nc5ccccc5N(C)S(C)(=O)=O)c5cc[nH]c5n4)cc3F)CC2)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50652205   

TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652205(CHEMBL5646609)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of EGFR del19/T790M/C797S triple mutant (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652205(CHEMBL5646609)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652205(CHEMBL5646609)
Affinity DataIC50: 7.40nMAssay Description:Inhibition of EGFR phosphorylation in human PC-9 cells harboring Del19/T790M/C797S mutant incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652205(CHEMBL5646609)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of EGFR phosphorylation in human A-431 cells harboring wild type EGFR incubated for 6 hrs by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Sungkyunkwan University

Curated by ChEMBL
LigandPNGBDBM50652205(CHEMBL5646609)
Affinity DataIC50: 1.03E+4nMAssay Description:Inhibition of wild type EGFR (unknown origin) in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed