BDBM50652288 CHEMBL5639385

SMILES Cc1cc(C)c(CNC(=O)c2cc(-c3ccc(F)cc3NC(=O)/C=C/CN(C)C)cc(N(C)C3CCOCC3)c2C)c(=O)[nH]1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50652288   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50652288(CHEMBL5639385)
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human N-terminal His-tagged EZH2 (2 to end residues) using [3H]-SAM as substrate preincubated for 15 mins followed by substrate additio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Chinese Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50652288(CHEMBL5639385)
Affinity DataIC50: 5.70nMAssay Description:Inhibition of EZH2 A677G mutant (unknown origin) using [3H]-SAM as substrate preincubated for 15 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed