BDBM50652668 CHEMBL5639978

SMILES FC1(F)CCNC[C@H]1CNc1nc(-c2ccc(N3CCOCC3)cc2)cc2nccnc12

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50652668   

TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 3nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 17nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 61nMAssay Description:Inhibition of his-tagged human recombinant KDR incubated for 60 mins by Z'lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652668(CHEMBL5639978)
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of KDR phosphorylation in VEGF-induced HEK293 cells preincubated with compound for 60 mins followed by VEGF-induction and measured after 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed