BDBM50652678 CHEMBL5639139

SMILES CC(=O)N1CCN(c2ccc(-c3cc4nccnc4c(NC[C@@H]4CNCCO4)n3)cc2F)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50652678   

TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652678(CHEMBL5639139)
Affinity DataIC50: 47nMAssay Description:Inhibition of Syk (unknown origin) incubated for 1 hr in presence of ATP by FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase SYK(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652678(CHEMBL5639139)
Affinity DataIC50: 51nMAssay Description:Inhibition of Syk (unknown origin) at 3 uM incubated for 1 hr in presence of ATP by FRET assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652678(CHEMBL5639139)
Affinity DataIC50: 193nMAssay Description:Inhibition of his-tagged human recombinant KDR incubated for 60 mins by Z'lyte assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
HUTCHMED Limited

Curated by ChEMBL
LigandPNGBDBM50652678(CHEMBL5639139)
Affinity DataIC50: 4.58E+3nMAssay Description:Inhibition of KDR phosphorylation in VEGF-induced HEK293 cells preincubated with compound for 60 mins followed by VEGF-induction and measured after 8...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed