BDBM50652891 CHEMBL5665391

SMILES COc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccn4)c(Cl)c3)c2cc1NC(=O)/C=C/CN(C)C

InChI Key

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50652891   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 2nMAssay Description:Inhibition of HER2 in human BT-474 cells assessed as reduction in MAPK phosphorylation incubated for 12 to 16 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 2nMAssay Description:Inhibition of HER2 in human BT-474 cells assessed as reduction in AKT phosphorylation incubated for 12 to 16 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 3nMAssay Description:Inhibition of EGF-induced EGFR phosphorylation in human A-431 cells incubated for 3 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 5nMAssay Description:Inhibition of HER2 autophosphorylation in human BT-474 cells measured after 3 hrs by Western blot analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant N-terminal His6-tagged HER2 cytoplasmic domain (676 to 1255 residues) (unknown origin) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetEpidermal growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 92nMAssay Description:Inhibition of recombinant N-terminal His6-tagged EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) expressed in baculovirus infected Sf...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 800nMAssay Description:Inhibition of recombinant KDR (unknown origin) using poly[Glu:Tyr] (4:1) as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant Src (unknown origin) using peptide as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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Target[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of recombinant PDK1 (unknown origin) using peptide as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of recombinant IKK-2 (unknown origin) using peptide as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant CDK1/cyclin B1 (unknown origin) using protein as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant c-Raf (unknown origin) using protein as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetMitogen-activated protein kinase kinase kinase 8(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant Tpl-2 (unknown origin) using peptide as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant CDK2/cyclin E (unknown origin) using protein as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetRAC-alpha serine/threonine-protein kinase(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of recombinant AKT (unknown origin) using peptide as substrateMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetHepatocyte growth factor receptor(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of recombinant c-Met autophosphorylation (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
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TargetMAP kinase-activated protein kinase 2(Human)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of recombinant MK2 (unknown origin) using peptide as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy BDB DOIPubMed
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TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Wyeth Research

Curated by ChEMBL

LigandBDBM50652891(CHEMBL5665391)Copy SMILES

Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of recombinant CDK4/cyclin D1 (unknown origin) using protein as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In Depth
Date in BDB:
10/13/2025
Entry Details
Copy BDB DOIPubMed
Copy reaction URL