BDBM50653010 CHEMBL5712062
SMILES C[C@H]1Oc2cc(cnc2N)-c2c(nn(C)c2C#N)CN(C)C(=O)C2C=CC(F)=CC21
InChI Key
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 21 hits for monomerid = 50653010
Affinity DataKi: <0.0250nMAssay Description:Binding affinity to recombinant human ROS1 assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataKi: <0.0700nMAssay Description:Binding affinity to recombinant ALK (unknown origin) assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Binding affinity to recombinant human ROS1 L2026M mutant assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.190nMAssay Description:Inhibition of SLC34A2-ROS1 fusion protein expressed in human HCC78 cells assessed as inhibition of phosphorylated ROS1 incubated for 1 hr by ELISA an...More data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:Inhibition of CD74-ROS1 expressed in mouse BaF3 cells assessed as inhibition of phosphorylated ROS1 incubated for 1 hr by ELISA analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of CD74-ROS1 expressed in mouse NIH3T3 cells assessed as inhibition of phosphorylated ROS1 incubated for 1 hr by ELISA analysisMore data for this Ligand-Target Pair
Affinity DataKi: 0.700nMAssay Description:Binding affinity to recombinant ALK L1196M mutant (unknown origin) assessed as inhibition constant in presence of ATP by microfluidic mobility shift ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of GST-tagged recombinant LTK (450 to 864 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 3.30nMAssay Description:Inhibition of His-tagged recombinant FER (541 to 822 residues) (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of His-tagged recombinant full length FES (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Binding affinity to recombinant human ROS1 G2032R mutant assessed as inhibition constant in presence of ATP by microfluidic mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-tagged recombinant full length PTK2B (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-tagged recombinant full length PTK2 (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of GST-tagged recombinant TNK2 (110 to 476 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of His-tagged recombinant TRKB (526 to 838 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Inhibition of His-tagged recombinant TRKA (441 to 796 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 46nMAssay Description:Inhibition of His-tagged recombinant TRKC (510 to 825 residues) (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 53nMAssay Description:Inhibition of GST-tagged recombinant full length FRK (unknown origin) expressed in baculovirus expression systemMore data for this Ligand-Target Pair
Affinity DataIC50: 56nMAssay Description:Inhibition of GST-tagged recombinant EGFR L858R/T790M mutant (668 to 1210 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 319nMAssay Description:Inhibition of GST-tagged recombinant EGFR T790M mutant (668 to 1210 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair
Affinity DataIC50: 529nMAssay Description:Inhibition of GST-tagged recombinant JAK2 (809 to 1153 residues) (unknown origin) expressed in Insect cellMore data for this Ligand-Target Pair