BDBM50653053 CHEMBL5723016

SMILES OCCn1cc(-c2cnc3nnn(Cc4cc5cccnc5cc4F)c3n2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50653053   

TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  3nMAssay Description:Inhibition of His6-tagged human c-Met H1094R mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  3nMAssay Description:Inhibition of un -tagged wild type human c-Met expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4Tyr) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  3nMAssay Description:Inhibition of His6-tagged wild type human c-Met expressed in Sf9 cells using (Glu4Tyr) or Met2 peptide substrate by coupled enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  49nMAssay Description:Inhibition of His6-tagged human c-Met Y1235D mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  157nMAssay Description:Inhibition of His6-tagged human c-Met L1195V mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of His6-tagged human c-Met Y1230H mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of His6-tagged human c-Met D1228H mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHepatocyte growth factor receptor(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50653053(CHEMBL5723016)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of His6-tagged human c-Met Y1230C mutant expressed in Sf9 cells pre-incubated with enzyme for 30 mins prior to addition of ATP using (Glu4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed