BDBM50654183 CHEMBL6103021

SMILES COc1ccc(-c2c(C#N)c(=O)n(Cc3ccccc3)c3c(N[C@H](C)c4ccccn4)cccc23)cc1

InChI Key InChIKey=FATDASVBFINTKE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50654183   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 3nMAssay Description:Inhibition of Nav1.5 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 20nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 3.38E+3nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 2.12E+4nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 2.57E+4nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 5.33E+4nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A(Human)
Southern Medical University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654183BDBM50654183(CHEMBL6103021)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Nav1.7 by cell based whole-cell voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed