BDBM50654854 ARISTOLACTAM BIII

SMILES COc1ccc2cc3c4c(cc(OC)c(OC)c4c2c1)C(=O)N3

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50654854   

LigandChemical structure of BindingDB Monomer ID 50654854BDBM50654854(ARISTOLACTAM BIII)
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at estrogen receptor alpha (unknown origin) assessed as inhibition of estradiol-induced response after 22 hrs by cell-based lucif...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetDual specificity protein kinase CLK1(Human)
Nirma University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654854BDBM50654854(ARISTOLACTAM BIII)
Affinity DataIC50: 50nMAssay Description:Inhibition of 20S immunoproteasome beta 2 (unknown origin) by cell based ABPP assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
TargetCyclin-dependent kinase 1(Human)
Nirma University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50654854BDBM50654854(ARISTOLACTAM BIII)
Affinity DataIC50: 405nMAssay Description:Induction of human APJ receptor internalization by cell based assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed
LigandChemical structure of BindingDB Monomer ID 50654854BDBM50654854(ARISTOLACTAM BIII)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human TLR4 expressed in HEK-Blue cells assessed as decrease in LPS-induced TLR4 response incubated for 1 hr followed by LPS stimulation...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details PubMed