BDBM50656491 CHEMBL6146719

SMILES O=C(N[C@H]1C[C@@H](c2ccccc2)CN(CC(F)(F)F)C1=O)c1ccc2c(c1)C[C@@]1(C2)C(=O)Nc2ncccc21

InChI Key InChIKey=DKUREEWHAQZNFI-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50656491   

LigandChemical structure of BindingDB Monomer ID 50656491BDBM50656491(CHEMBL6146719)
Affinity DataKi:  0.840nMAssay Description:Displacement of 125I-hCGRP from human CLR/RAMP1 receptor expressed from HEK293 cell membrane coexpressing CLR/RAMP1 assessed as dissociation constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetSodium-dependent dopamine transporter(Human)
Merck & Co.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656491BDBM50656491(CHEMBL6146719)
Affinity DataIC50: 720nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50656491BDBM50656491(CHEMBL6146719)
Affinity DataKi:  810nMAssay Description:Binding affinity to AM2 complex of CLR/RAMP1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetSodium channel protein type 5 subunit alpha(Human)
Merck & Co.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656491BDBM50656491(CHEMBL6146719)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed