BDBM50656742 CHEMBL6168241

SMILES C=CC(=O)Nc1cccc(Nc2nc(Nc3cnn(C)c3)ncc2Cl)c1

InChI Key InChIKey=XSJRZSVAMQBQHP-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50656742   

TargetEpidermal growth factor receptor(Human)
King Mongkut's Institute of Technology Ladkrabang

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656742BDBM50656742(CHEMBL6168241)
Affinity DataKi:  3.80nMAssay Description:Binding affinity to wild type EGFR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
King Mongkut's Institute of Technology Ladkrabang

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656742BDBM50656742(CHEMBL6168241)
Affinity DataIC50: 21nMAssay Description:Inhibition of EGFR DM T790M/L858R mutant (unknown origin) using poly (Glu:Tyr) as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase a...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
King Mongkut's Institute of Technology Ladkrabang

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656742BDBM50656742(CHEMBL6168241)
Affinity DataIC50: 70nMAssay Description:Inhibition of JAK3 (unknown origin) using poly (Glu:Tyr) as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
King Mongkut's Institute of Technology Ladkrabang

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50656742BDBM50656742(CHEMBL6168241)
Affinity DataIC50: 174nMAssay Description:Inhibition of wild type EGFR (unknown origin) using poly (Glu:Tyr) as substrate incubated for 1 hr in presence of ATP by ADP-glo kinase assayMore data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed