BDBM50657504 CHEMBL6164725

SMILES CNC[C@@H](Cc1ccc(Cl)cc1)N(C)C(=O)C[C@H]1CCCN1C(=O)c1cncc2ccccc12

InChI Key InChIKey=GXPQYYAGECLWNZ-UHFFFAOYSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50657504   

TargetReplicase polyprotein 1ab(2019-nCoV)
Arbutus Biopharma Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657504BDBM50657504(CHEMBL6164725)
Affinity DataKi:  28nMAssay Description:Binding affinity to wild type SARS-CoV-2 main protease expressed in Escherichia coli assessed as inhibition constant using fluorogenic substrate incu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Arbutus Biopharma Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657504BDBM50657504(CHEMBL6164725)
Affinity DataIC50: 79nMAssay Description:Inhibition of N/C terminal SARS-CoV-2 main protease extracted from Escherichia coli using EDANS-VNSTLQSGLRK-(Dabcyl)M as substrate preincubated for 3...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetProcathepsin L(Human)
Arbutus Biopharma Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657504BDBM50657504(CHEMBL6164725)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of cathepsin L (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed
TargetCathepsin B(Human)
Arbutus Biopharma Inc.

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50657504BDBM50657504(CHEMBL6164725)
Affinity DataIC50: 4.40E+4nMAssay Description:Inhibition of cathepsin B (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/4/2026
Entry Details
PubMed