BDBM50659204 CHEMBL6120904

SMILES N#C/C(=Cc1ccc(O)c(O)c1)C(=O)Nc1nc(-c2ccccc2)cs1

InChI Key InChIKey=PQVANVSDCRSXBG-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50659204   

TargetDouble-strand break repair protein MRE11(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659204BDBM50659204(CHEMBL6120904)
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of human MRE11 expressed in insect High Five cells using fluorescent-labeled 5'-overhang DNA as substrate preincubated for 20 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDouble-strand break repair protein MRE11(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659204BDBM50659204(CHEMBL6120904)
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of MRE11 in human U2OS cells assessed as inhibition of pS4/S8 RPA 32 level incubated for 1 hr followed by treatment with camptothecin for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDouble-strand break repair protein MRE11(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659204BDBM50659204(CHEMBL6120904)
Affinity DataIC50: 2.53E+4nMAssay Description:Inhibition of human MRE11 expressed in insect High Five cells using fluorescent-labeled 5'-overhang DNA as substrate preincubated for 20 mins followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetDouble-strand break repair protein MRE11(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659204BDBM50659204(CHEMBL6120904)
Affinity DataIC50: 3.80E+4nMAssay Description:Binding affinity to MRE11 in human U2OS cells assessed as destabilization of protein incubated for 60 mins followed by exposure to temperature of 49 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetFlap endonuclease 1(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659204BDBM50659204(CHEMBL6120904)
Affinity DataIC50: 8.27E+4nMAssay Description:Inhibition of human FEN1 expressed in Escherichia coli cells using 5'-Flap DNA as substrate preincubated for 20 mins followed by substrate addition a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetExonuclease 1(Human)
Masaryk University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659204BDBM50659204(CHEMBL6120904)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human EXO1 expressed in Escherichia coli BL21 (RIPL) cells using 3'-overhang DNA as substrate preincubated for 20 mins followed by subs...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed