BDBM50659452 CHEMBL6144797

SMILES CNc1nc(Nc2ccc(N3CCOCC3)cc2C#N)c(C(N)=O)nc1-c1cncc2c1ncn2C

InChI Key InChIKey=MFNPNFYOUDTBOL-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50659452   

LigandChemical structure of BindingDB Monomer ID 50659452BDBM50659452(CHEMBL6144797)
Affinity DataIC50: 160nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant HPK1 (1 to 346 residues) expressed in Insect cell using LRRKtide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
LigandChemical structure of BindingDB Monomer ID 50659452BDBM50659452(CHEMBL6144797)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant GLK (1 to 380 residues) expressed in insect cells using LRRKtide as substrate preincubated for ...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetTyrosine-protein kinase Lck(Human)
AstraZeneca

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659452BDBM50659452(CHEMBL6144797)
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human recombinant LCK expressed in insect cells using EQEDEDEPEGIYGVLE-amide as substrate preincubate...More data for this Ligand-Target Pair
Ligand Info
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed