BDBM50659688 CHEMBL6169362

SMILES [2H]C([2H])([2H])n1cc(-c2ccnc(Nc3cc(NC(=O)C=C)c(N4CC[C@@H](N(C)C)C4)cc3OC)n2)c2ccccc21

InChI Key InChIKey=XBVQISMCXPSCBG-GKOSEXJESA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50659688   

TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659688BDBM50659688(CHEMBL6169362)
Affinity DataIC50: 0.600nMAssay Description:Inhibition of full-length recombinant LSD1 (123 to 852 residues)(unknown origin)/CoREST (305 to 482 residues)(unknown origin) extracted from Escheric...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659688BDBM50659688(CHEMBL6169362)
Affinity DataIC50: 3.80nMAssay Description:Inhibition of EGFR L858R/T790M mutant (unknown origin) using Glu/Tyr as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetREST corepressor 1(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659688BDBM50659688(CHEMBL6169362)
Affinity DataKi:  257nMAssay Description:Non-competitive inhibition of LSD1/CoREST (unknown origin) using H3K4me2 as substrate incubated for 0.5 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Zhengzhou University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50659688BDBM50659688(CHEMBL6169362)
Affinity DataIC50: 268nMAssay Description:Inhibition of wild-type EGFR (unknown origin) using Glu/Tyr as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
6/5/2026
Entry Details
PubMed