BDBM50660327 CHEMBL6172851
SMILES COc1ccc(NC(=O)C(C)n2nc(C(=O)Nc3ccccc3)c3ccccc32)cc1
InChI Key InChIKey=RMFSSCRIIFISSY-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 15 hits for monomerid = 50660327
TargetSolute carrier organic anion transporter family member 2B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 387nMAssay Description:Inhibition of OATP2B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of pyranine uptake preincubated for 5 mins followed by...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 939nMAssay Description:Reversal of ABCG2 (unknown origin)-mediated multidrug resistance transfected in dog MDCK-II-BCRP cells assessed as increase in SN-38-mediated cytotox...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1A2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 991nMAssay Description:Inhibition of OATP1A2 (unknown origin) transfected in human A-431 cells assessed as inhibition of SR101 uptake preincubated for 5 mins followed by SR...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 2.49E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in calcein-AM fluorescence intensity using calcein-AM as tracer preincubated for 30...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1B3(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 3.36E+3nMAssay Description:Inhibition of OATP1B3 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
TargetMonocarboxylate transporter 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 4.34E+3nMAssay Description:Inhibition of MCT-1 in human A549 cells assessed as potentiation of 3-BP-mediated cytotoxicity by measuring decrease in cell viability incubated for ...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 4.75E+3nMAssay Description:Reversal of ABCB1-mediated multidrug resistance in human A2780 ADR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 6.83E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in Hoechst 33342 fluorescence intensity using Hoechst 3...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 7.58E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 8.49E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 8.93E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 9.55E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in rhodamine123 fluorescence intensity using rhodamine123 as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 9.64E+3nMAssay Description:Reversal of ABCC1-mediated multidrug resistance in human NCI-H69AR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 2.71E+4nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in pheophorbide A fluorescence intensity using pheophor...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier family 22 member 2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.18E+5nMAssay Description:Inhibition of OCT2 (unknown origin) expressed in HEK293 cells assessed as inhibition of ASP+ uptake incubated for 5 mins by fluorescence based analys...More data for this Ligand-Target Pair
Ligand Info