BDBM50660329 CHEMBL6161092
SMILES CC(C(=O)Nc1ccccc1)n1nc(C(=O)Nc2ccc(Cl)cc2)c2ccccc21
InChI Key InChIKey=JLKDPYRKWSTGAC-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50660329
TargetSolute carrier organic anion transporter family member 2B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 402nMAssay Description:Inhibition of OATP2B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of pyranine uptake preincubated for 5 mins followed by...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 2.17E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in Hoechst 33342 fluorescence intensity using Hoechst 3...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 5.48E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 6.61E+3nMAssay Description:Inhibition of ABCC1 in human NCI-H69AR cells assessed as increase in rhodamine123 fluorescence intensity using rhodamine123 as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 7.57E+3nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in calcein-AM fluorescence intensity using calcein-AM as tracer preincubated for 30...More data for this Ligand-Target Pair
Ligand Info
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 7.89E+3nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in dog MDCK-II-BCRP cells assessed as increase in pheophorbide A fluorescence intensity using pheophor...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1A2(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 7.93E+3nMAssay Description:Inhibition of OATP1A2 (unknown origin) transfected in human A-431 cells assessed as inhibition of SR101 uptake preincubated for 5 mins followed by SR...More data for this Ligand-Target Pair
Ligand Info
TargetMonocarboxylate transporter 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.11E+4nMAssay Description:Inhibition of MCT-1 in human A549 cells assessed as potentiation of 3-BP-mediated cytotoxicity by measuring decrease in cell viability incubated for ...More data for this Ligand-Target Pair
Ligand Info
TargetATP-dependent translocase ABCB1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of ABCB1 in human A2780 ADR cells assessed as increase in daunorubicin fluorescence intensity using daunorubicin as tracer preincubated fo...More data for this Ligand-Target Pair
Ligand Info
TargetMultidrug resistance-associated protein 1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataEC50: 1.23E+4nMAssay Description:Reversal of ABCC1-mediated multidrug resistance in human NCI-H69AR cells assessed as increase in doxorubicin-mediated cytotoxicity incubated for 72 h...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1B3(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of OATP1B3 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info
TargetSolute carrier organic anion transporter family member 1B1(Human)
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
University of Lubeck and University Medical Center Schleswig-Holstein
Curated by ChEMBL
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of OATP1B1 (unknown origin) transfected in human A-431 cells assessed as inhibition of DHPDS uptake preincubated for 5 mins followed by DH...More data for this Ligand-Target Pair
Ligand Info